THE INDIAN INSTITUTE OF SCIENCE, BANGALORE
The Indian Institute of Science, Bangalore, founded in 1909, is a premier research institution in the country. It has about 500 eminent faculty members, 1,500 students and 1,500 support staff. The different departments in the institute are grouped into five divisions, namely, the Divisions of Biological Sciences, Chemical Sciences, Electrical Sciences, and Physical and Mathematical Sciences. The mainstay of the institute is world class research at the cutting edge of science and engineering, and teaching and training at the highest level. Sponsored research, especially on problems, of national importance, industrial interactions, continuing education and application of science and technology for rural development are the other facets of the activities of the institute. 
The Division of Biological Sciences, made up of five departments and three facilities, is involved in frontline research in almost all aspects of modern biology. A substantial part of the activities of about 50 faculty members and more than 250 research students and post-doctoral fellows in the division come under three broad categories, namely, infectious diseases, drug and molecular design, and genetic disorders, gene disorders and genetic diversity. 
The Department of Biotechnology, among other things, provides programme support in these areas in the form of major facilities. In addition to carrying out excellent fundamental research in modern biology, particular attention is paid to the applications that flow from it.

The Bioinformatics Centre at the Indian Institute of Science was established in 1987 with specialization in the area of Genetic Engineering. This is one of the core facility in the field of biotechnology providing access to the latest information of the world's databases in the fields of genetic engineering, sequence and structure and functioning of biomolecules. The centre moved into its newly constructed premises at the Department of Physics in 1989, Indian Institute of Science, where it is now equipped with the state-of-the-art facilities in terms of hardware, software, networks, etc. The hardware includes DEC Alpha, MICROVAX, INDY Workstation, VGX Silicon Graphics Workstation, Pentium PCs, Multimedia workstations, Micro Earth Station, PCs and LAN. 

The centre provides services for the Biocomputational research, Sequence Analysis, Crystallographic Data Analysis, and Computerised Bibliographic Searches, etc. The state-of-the-art Sequence Analysis programme GCG (version 9.0), Oligo Primer Analysis Software and Staden's Sequence Analysis Package, have been widely used by the scientific community from this centre. The centre has accumulated a variety of CD-based databases for making them available to the users. These include : GenBank and EMBL Nucleotide Sequence, SWISS and PIR Protein Sequence, PDB-Protein, MycDB-Integrated Myobacterial, AAtDB-Arabidopsis thaliana, Yeast Genome and MEDLINE Databases. Some of the Databases mirrored at the centre include : SCOP-Structural Classification of Proteins, Database, etc. (URL : http://physics.iisc.ernet.in/bioinf.htm/scop). 

The services provided by the centre include Sequence analysis, Offline bibliographic search through CD-ROMs like database search, literature search, and online bibliographic search through network like Internet search, Mathematical modelling, Simulation and Graphics Applications, Application Development, Statistical Analysis, etc. The centre also provides training to the students, teachers and workers in the field of biology in bioinformatics. For this the centre is organizing workshops from time to time and a regular teaching course is being offered to incoming research students on "The Analysis of Nucleic Acid and Protein Sequences and Structures." The centre also publishers a bimonthly newsletter giving information on some of the latest developments in the area of Bioinformatics. The centre has recently published a HOME PAGE of the centre for better awareness of the user about the centre. Over the last 10 years nearly 50 scientific papers and a growing number of Ph.D. theses have acknowledged the usage of the facilities of this centre. The staff of the Bioinformatics centre are also involved in research and have a number of publications to their credit. 

During early 1990s, a National Facility for Interactive Graphics for Biomolecular Modelling, Dynamics and Structure was established in the institute under the BTIS programme, to provide services to whole Southern Region. As a part of this facility a state-of-the-art Graphics Workstation (VGX-310 Silicon Graphics), a Silicon Graphics Personal IRIS Workstation and a Wipro Landmark 860 were installed along with versatile Molecular modelling package. This facility is now being extensively used by the scientists for the studies of biomolecular modelling. The number of external users is growing rapidly. Several scientific papers are coming out from this facility. 

The centre has expanded its user base significantly over the last few years. Apart from the host and neighbouring institutes, scientists from distant places are also utilising the facilities of the centre. 

CONTACT FOR DETAILS

Dr. S. Ramakumar
Bioinformatics Centre 
Department of Physics 
Indian Institute of Science 
Malleswaram, Bangalore - 560 012. 
Phone : 080-3092478, 3092286, 3345409,3092469 
Fax : 91-80-3344551, 3341683, 3342085 
Telex : 0854-8349 BG 
E-mail : bioinf@physics.iisc.ernet.in
 ramk@physics.iisc.ernet.in
 sekar@physics.iisc.ernet.in